The undeniable influence of soil-structure interaction on the behavior of structures, along with the increasing importance of explosive loads in the current global security context, has led to the modeling and sensitivity analysis of the effects of distance and explosive loads on concrete structures. In this study, three types of structures with 3, 7 and 15 stories were investigated. ETABS and ABAQUS software were used, with ETABS for the design of structural elements and ABAQUS for the analysis of soil-structure interaction effects. The results showed that increasing the distance of the explosion from the structure significantly reduces the force generated by the explosion, while increasing the weight of the explosive materials increases the applied force. However, the effect of distance is more pronounced compared to variations in TNT weight. The input energy and the induced displacements in the structures showed a significant correlation with the blast force. In all three structures studied, increasing the distance or decreasing the weight of the explosives resulted in reduced energy and displacement. In addition, increasing the number of stories significantly increased the displacements, with the 15-story structure experiencing greater displacement and energy absorption compared to the other structures. The damage pattern also varied; for example, in the 3-story structure, damage was observed primarily in the upper floors, in the 7-story structure, in the middle floors, and in the 15-story structure, in the lower floors. Maximum displacement occurred in the upper floors of the 3-story structure, the middle floors of the 7-story structure, and the lower floors of the 15-story structure. Overall, this study demonstrates a significant relationship between input energy, induced displacements, and explosive force in all three structures. The samples investigated in this study include three concrete medium moment frame structures: low-rise (3-story), mid-rise (7-story), and high-rise (15-story), under different conditions with and without consideration of soil-structure interaction. In order to evaluate the effect of soil-structure interaction on the behavior of concrete frames according to seismic regulations, three models were designed and categorized into 3, 7, and 15-story groups. Each of these three groups was analyzed and designed as a three-dimensional model using Etabs software. The distance between the explosion and the structure significantly affects the magnitude of the applied force, with the force decreasing sharply as the distance increases. The table below shows models S1 through S7 and the distances of a 100-kilogram explosive from the structure. The results of the analysis of models S1 through S7 are presented and discussed. In these models, the impact of a 100-kilogram TNT explosion on the middle floor of a 7-story building is applied at various distances between the center of the explosion and the building. It is observed that increasing the explosion distance significantly reduces the resulting displacement, with a particularly sharp decrease. It is also evident that increasing the blast distance beyond 1 meter results in a dramatic reduction in the stress exerted on the structure. Then, one frame of the designed models was simulated in ABAQUS software and its performance under two conditions-with and without soil-structure interaction-was evaluated by comparing parameters such as maximum roof displacement, bearing capacity, and stress among the models. Urban development is increasing construction demand due to limited space and high costs. High-rise buildings are popular due to hard-soiled sites, which constitute a significant portion of existing structures. Iran's location necessitates consideration of all possible scenarios. This article begins with an introduction to concrete moment frames on hard soils, including explosive loading. The second section discusses previous research and the theoretical foundations of methods for analyzing these systems. The third section presents the finite element method, ABAQUS software, and response validation. The fourth section discusses the results of designing and analyzing finite element models of 3-, 7-, and 15-story structures against explosion loads. This section ends with general findings and recommendations for future research. The main findings of this research can be summarized as follows: Increasing the number of stories results in significantly larger displacements, with the 15-story structure exhibiting more displacement and energy absorption than the other structures. The blast load spectrum is applied to the structure in two phases: compression and tension. Although the absolute magnitude of the tensile force in the blast spectrum is much smaller than the force in the initial compression phase, it is observed that after the completion of the compression phase, significant damage occurs during the reverse pressure phenomenon in the blast.